CombiND - role of sequence space expansion in improving homology detection

In order to improve the homology detection through designed intermediates, artificial expansion of the sequence space around protein families was carried out.

However, it was found that the relationships within the protein family improved but was compromised at the structural fold level. This was based on the performance in twenty folds.

One of the explanations could be the over-representation and poor sampling of the sequence space by these family-specific artificial sequences.