Recognition of vicinal and distant functional relationships

The protein families are often grouped into clans based on functional relatedness driven by similar sequence signatures or structural motifs. As the sequence similarity shared becomes marginal it becomes challenging to an evolutionary relationship.  We plugged the designed sequences into Pfam to identify new functional relationships between families.

As assessment,  many fold associated families were queried and other structural fold members were identified as hits.

Our method enhanced the number of pairwise relationships including new connections not reported thus far. (A comparison with hhsearch).

We were also able to identify new sub groups of related protein families and examined the biological relevance of the associations for a few.